Kisakye was battling an unknown illness.
She was hospitalised at Mulago two weeks ago with a septic wound on her fore arm but her condition kept getting worse.
Harriet was on Thursday moved from Mulago to International Hospital Kampala after her condition became more complicated for Mulago.
Former FDC president Kizza Besigye reportedly deposited 5M Ugx at IHK in hopes that the singer got better but it is so unfortunate that she couldn't beat the strange illness.
Some reports say Kisakye had liver, kidney and lung complications and the organs were not functioning well.